Collegium Helveticum

Sample Delivery Methods
For In-Situ Studies and Serial Crystallography


Venue & accessibility info: Meridian Hall, Collegium Helveticum

This is a public event. Participation is free of charge and registration is not required.

The workshop is followed by a small reception.

X-ray Free Electron Lasers (XFEL) can generate extremely bright and ultrafast X-ray pulses to determine structural properties of complex biomolecules at an atomic scale, and, create ‘molecular movies’ capturing rapid chemical processes with unprecedented temporal resolution. The high intensity of the X-rays destroys the studied samples immediately after detailed information is extracted. Consequently, fresh samples need to be delivered continuously, in sync with incoming X-ray pulses. This constitutes a key challenge for XFEL data collection.

This workshop brings together chemists, structural biologists, beamline scientists, and engineers to explore the latest advancements in sample delivery techniques for X-ray sources, with a specific focus on in-situ monitoring of bio-chemical reactions and serial crystallography.



Opening and welcome remarks
Tuncay Alan


Droplet-Based Microfluidics for High-Throughput Chemistry
Andrew deMello (ETH Zurich)


Science in Arts and the Art of Science: Injecting Carpets and Microdroplets in X-Ray Microscopes
Thomas Huthwelker (Paul Scherrer Institute)


Sample Delivery Methods for Protein Crystallography at SwissFEL Alvra
Emma Victoria Beale (SwissFEL & Paul Scherrer institute)


Coffee break


High Repetition Rate (And Other) Sample Delivery for European XFEL
Joachim Schulz (European XFEL)


Imaging Isolated Nanoparticles and Their Ultrafast Dynamics
Daniela Rupp (ETH Zurich)


The XFEL Hub at Diamond: Dynamic Structural Biology on Earth
Allen Orville (Diamond Light Source)


Developing Fixed-Target Instrumentation for Time-Resolved Crystallography at the Swissfel Cristallina Experimental Station
Michal Kepa (Paul Scherrer Institute)


Closing remarks, followed by a small reception with drinks

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